ION Gut Support Supplement Science

Science that reflects nature's wisdom

The ION* suite is founded on the principle of letting the intelligence of nature lead the way. Just as importantly, science is a process we hold sacred. Astute observation allows us the opportunity to learn the intricacies of nature. We rely on rigorous testing with evidence gathered from the natural world to understand how we are interconnected. While nature holds the answers, it is inherent upon us to shed light on her wisdom.

  • How ION* works

    The science behind ION* lies in strengthening the cellular integrity of your body's barriers, including not just your gut, but your sinuses and skin as well. Keeping your cells connected keeps these barriers intact, which sets the stage (or "terrain" as we like to call it) for seamless interaction between you and your microbiome.

    • Connection

      At ION*, we're all about connection – starting with the very foundation of our science: tight junction integrity. Tight junctions are the seals between your cells which help to create defensive barriers at the gut, skin, and sinuses. They act intelligently to keep toxins and foreign particles out of the blood stream while also allowing nutrients to enter. These seals are protected by the carbon and mineral metabolites of bacterial digestion.

      Unfortunately, tight junction barriers can be degraded with exposure to gluten, glyphosate (the main chemical in commercial herbicides like Roundup), and other environmental insults. ION* has been scientifically shown to promote the strengthening of this barrier through redox signaling, even in the face of those environmental insults.

      ION Gut and Digestive Health Support Diagram

    • Communication

      Redox signaling is perhaps the most complex aspect of our science. And yet, at its core, it's simply how your cells communicate.

      Redox signaling is a fundamental network, a fluency of electrons, moving in lightning fast patterns through the cell. Mitochondria (organelles within the cell) generate redox signals as they create electrical power to fuel biology. Cells monitor these signals as sets of instructions.

      Reactive oxygen species (or ROS) are also a fundamental part of the process. Natural byproducts of cellular metabolism, ROS function in two ways – by promoting the signaling that maintains physiological functions and by causing oxidative stress.

      A good balance is ultimately the goal. This is why ION* works so well; it fosters communication within your unique system, helping to promote balance.

    • Our innovative spark

      Terrahydrite®, the innovative blend utilized across our entire ION* line, functions as a signal, not a nutrient, selectively inducing appropriate modulation of ROS depending on the condition of the cell. This means it helps to reduce ROS in healthy cells (which indicates greater efficiency in energy production), and increases ROS in cells which need immune intervention or repair.

      We call this the intelligence of nature, because rather than forcing response at the cellular level, the signaling molecules in ION* amplify the cells’ own communication pathways, resulting in appropriate adaptation to the intracellular and extracellular environment.

      But, how?

      Well, the ancient soil from which ION* is derived contains the same redox signaling molecules that are naturally produced by your own bacteria. These bacterial metabolites reinforce the communication network that already exists within you.

      By supporting a beneficial shift in bacterial composition, ION* helps cultivate the types of microbes that reinforce your cellular integrity…and by reinforcing cellular integrity, ION* strengthens the terrain upon which your microbiome resides, further promoting its ability to diversify and thrive. Talk about symbiosis.

  • Our skin science goes a few steps further

    While much of the foundational science for ION* applies to our Skin Support product, there are other mechanisms at play here as well.

    • Reformulated for a new terrain

      ION* Skin Support is specially formulated to work with keratinocytes, the primary cells forming your skin barrier.

      Graph of TEER Increase in Skin Cells with ION* Skin Health Spray

      TEER is the means by which we measure cellular integrity. We see a significant increase for skin cells when utilizing our specially formulated Skin Support.

    • Balance your relationship with the sun

      Exposure to the sun results in the formation of reactive oxygen species (or ROS) on your skin. And too much exposure to intense UV results in cell damage. While ROS can be beneficial, whether they signal to cells (normal messaging) or damage them depends on a delicate balance. This is the strength of ION* - it helps to naturally stabilize ROS production associated with sun exposure.

      Graph of Stabilized ROS Production with ION* Gut Health

      ION* Skin Support works to naturally balance production of reactive oxygen species in response to UVB.

    • Beyond balance, antioxidants are key

      Glutathione is a powerful antioxidant made by your body and found in almost every cell. It is critical to preventing damage and resultant disease caused by reactive oxygen species. Glutathione helps to:

      • Neutralize free radicals
      • Boost immune function
      • Detoxify the body
      Graph of Glutathione Levels with ION* Gut Health
  • Our core benefits

    • ION Gut and Digestive Health Supplement Bottle Bundle Science
      Toxin protection

      Your body's barriers know what to let in (nutrients) and what to ward off (toxins). But the barriers must be strong. ION* works to strengthen your gut, sinus, and skin barriers at a cellular level by fostering tight junction integrity, helping to promote this intelligent defense system at a foundational level.

    • ION Purified Water Icon
      Immune function

      Your immune system's function is to identify and eradicate pathogens, and that process begins at your body's barriers to the outside world. Research indicates that 70% or more of the body’s pathogen-fighting white blood cells reside in the gut. By helping to keep your barriers strong, ION* displaces pathogens before your immune system is exposed to their damaging effects.

    • ION Terrahydrite Icon
      Microbiome support

      Just like you, your microbiome needs a healthy, hospitable environment to thrive. Think of your skin, gut lining, and nasal passages as terrains – upon which the health of your microbiome depends. This is where we come in. By supporting the terrain (cellular integrity), ION* facilitates microbiome health at its literal foundation.

    • ION Amino Acid Icon
      Cellular hydration

      Healthy membranes (skin, gut, sinuses) facilitate movement of minerals and nutrients across cell membranes, also pulling in water. By improving cellular integrity and reinforcing those membranes, ION* improves the regulation of water absorption.

      Stronger tight junctions = better nutrient absorption and hydration.

    • Ion gut support collagen production icon
      Collagen production

      Collagen is most associated with improving elasticity, supporting hydration, and reducing signs of aging in the skin. However, the benefits of healthy collagen formation go far deeper, helping with everything from muscle strength to joint pain to heart health. ION* has been scientifically shown to support lysine production – one of the fundamental precursors of collagen formation.

ION Gut and Digestive Health Supplement Bottle Science
  • Our science

    Want to dig deeper? Our studies can provide even more insight.
    • Lysine production

      Shows the ability of ION* to promote the gut microbiome production of lysine by which it is expected to play an important role in protein production, epigenetic regulation, collagen production, immune system regulation, and a variety of cell processes.

    • Blood-brain barrier response

      Explores the connection between the microbiome and the gut and blood-brain barrier systems, as well as the improved effect that ION* has on the blood-brain barrier.

    • Immune function

      Validates the marked effect that ION* has on reducing zonulin, IL-6 (an inflammatory marker), and glyphosate in adult humans over a two-week course.

    • Glyphosate protection

      Establishes the capacity of ION* to block glyphosate-mediated injury in small intestinal and colon epithelial membranes.

    • Gluten impact

      Reveals that the addition of ION* stabilizes tight junction integrity even in the face of gluten exposure.

    • Pet support

      Shows the positive impact that ION* Gut Support For Pets has on barrier integrity across six species.